Publications
Scott, M.D., Murad, K.L., Koumpouras, F., Talbot, M., and Eaton, J.W. Chemical camouflage of antigenic determinants: “Stealth” erythrocytes. Proc. Nat. Acad. Sci. USA, 94:7566-7571(1997).
Scott, M.D. and Murad, K.L. Cellular camouflage: Fooling the immune system with polymers. Current Pharmaceutical Design, 4:423-438(1998).
Murad, K.L., Mahany, K.L. Kuypers, F.A., Brugnara, C., Eaton, J.W, and Scott, M.D. Structural and functional consequences of antigenic modulation of red cells with methoxypoly(ethylene glycol). Blood, 93:2121-2127(1999).
Murad, K.L., Gosselin, E.J., Eaton, J.W. Scott, M.D. Stealth Cells: Prevention of MHC Class II mediated T cell activation by cell surface modification. Blood, 94:2135-2141(1999).
Scott, M.D. Bradley, A.J., and Murad, K.L. Camouflaged Blood Cells: Low technology bioengineering for transfusion medicine? Transfusion Medicine Reviews, 14:53-63.(2000)
Chen, A.M. and Scott, M.D. Current and Future Applications of Immunologic Attenuation Via PEGylation of Cells and Tissues. BioDrugs, 15:833-847(2001).
Bradley, A.J. Test, T.T., Murad, K.L., Mitsuyoshi, J. and Scott, M.D. Interactions of IgM ABO Antibodies and complement with methoxy-PEG-modified human RBCs. Transfusion, 41:1225-1233(2001).
Bradley, A.J., Murad, K.L., Regan, K.L., and Scott, M.D. Biophysical consequences of linker chemistry and polymer size on stealth erythrocytes: Size does matter. Biochimica et Biophysica Acta, 1561:147-58(2002).
Chen, A.M. and Scott, M.D. Immunocamouflage: Prevention of transfusion-induced graft-versus-host disease via polymer grafting of donor cells. Journal of Biomedical Materials Research, 67A:626-636(2003).
Scott, M.D. Bradley, A.J., and Murad, K.L. Stealth Erythrocytes: Effects of polymer grafting on biophysical, biological and immunological parameters. Blood Transfusion, 1(3):245-266(2003).
Scott, M.D., and Chen, A.M. Beyond the red cell: Pegylation of other blood cells and tissues (Traitement par PEG des celllules sanguines et autres tissus). Transfusion Clinique et Biologique, 11:40-46(2004).
Bradley, A.J. and Scott, M.D. Separation and purification of methoxypoly(ethylene glycol) grafted red blood cells via two-phase partitioning. J. Chromatogr. B., 807:163-168 (2004).
McCoy, L.L and Scott, M.D. Broad spectrum antiviral prophylaxis: Inhibition of viral infection by polymer grafting with methoxypoly(ethylene glycol). In: Antiviral Drug Discovery for Emerging Diseases and Bioterrorism (Editor: Torrence, P.F.) Wiley & Sons, Hoboken, NJ. pp. 379-395.(2005).
Chen, A.M. and Scott, M.D. Immunocamouflage: Comparative analysis of polymer and linker chemistries on the efficacy of immunocamoulfage of murine cells. Artificial Cells, Blood Substitutes, and Biotechnology, 34:305-322(2006).
Bradley, A.J. and Scott, M.D. Immune complex binding by immunocamouflaged [poly(ethylene glycol)] erythrocytes. Am. J. Hematology, 82:970-975(2007).
Le, Y. and Scott, M.D. Immunocamouflage: The Biophysical Basis of Immunoprotection by Grafted Methoxypoly(Ethylene Glycol) [mPEG]. Acta Biomaterialia, 6:2631-2641 (2010).
Sutton, T.C. and Scott, M.D. The Effect of Methoxypoly(Ethylene Glycol) Chain Length on the Inhibition Of Respiratory Syncytial Virus (RSV) Infection And Proliferation. Biomaterials, 31:4223-2230 (2010).
Kyluik, D.L., Sutton, T.C., Le, Y. and Scott, M.D. Chapter 7: Polymer-Mediated Broad Spectrum Antiviral Prophylaxis: Utility in High Risk Environments. In: Progress in Molecular and Environmental Bioengineering- From Analysis and Modeling to Technology Applications (Editor: Carpi, A.) Intech, ISBN 978-953-307-268-5. pp. 167-190 (2011). Link: Intech Web Page
Wang, D., Kyluik, D.L, Murad, K.L., Toyofuku, W.M., and Scott, M.D. Polymer-Mediated Immunocamouflage of Red Blood Cells: Effects of Polymer Size on Antigenic and Immunogenic Recognition of Allogeneic Donor Blood Cells. Science China – Life Sciences, 54:589-598 (2011). [NOTE: Cover Art and featured article]
Wang, D., Toyofuku, W.M., Chen, A.M. and Scott, M.D. Induction of Immunotolerance via mPEG Grafting to Allogeneic Leukocytes. Biomaterials 32:9494-9503 (2011).
Wang, D., Toyofuku, W.M., Scott, M.D. The Potential Utility of Methoxypoly(Ethylene Glycol)-Mediated Prevention of Rhesus Blood Group Antigen RhD Recognition in Transfusion Medicine. Biomaterials, 33:3002-3012. (2012)
Wang, D., Toyofuku, W.M. Kyluik, D.L. and Scott, M.D. Chapter 7: Use of Flow Cytometry In The In Vitro and In Vivo Analysis of Tolerance/Anergy Induction By Immunocamouflage. In: Flow Cytometry-Recent Perspectives, (Editor: Schmid, I.) InTech, ISBN 979-953-307-355-1. (2012). Pages 133-150. Link: Intech Web Page
Le, Y. Li, L., Wang, D. and Scott, M.D. Immunocamouflage of Latex Surfaces by Grafted Methoxypoly(Ethylene Glycol) [mPEG]: Proteomic Analysis of Plasma Protein Adsorption. Science China - Life Sciences, 55:191-201 (2012). [NOTE: Cover Art and featured article]
Kyluik-Price D.L., Li, L. and Scott, M.D. Comparative Efficacy of Blood Cell Immunocamouflage by Membrane Grafting of Methoxypoly(Ethylene Glycol) and Polyethyloxazoline. Biomaterials 35(1):412-422 (2014).
Li, L., Noumsi, G.T., Kwok, Y.Y.E., Moulds, J.M. and Scott, M.D. Inhibition of Phagocytic Recognition of Anti-D Opsonized Rh D+ RBC By Polymer-Mediated Immunocamouflage. American Journal of Hematology, 90(12):1165-1170 (2015).
Wang, D., Shanina , I., Toyofuku, W.M., Horwitz, M.S. and Scott, M.D. Inhibition of Autoimmune Diabetes in NOD Mice by miRNA Therapy. PLoS ONE 10(12): e0145179. doi:10.1371/journal. pone.0145179 (2015). Link: Plosone Paper
Kyluik-Price D.L., Li, L. and Scott, M.D. Effects of Methoxypoly (Ethylene Glycol) Mediated Immunocamouflage on Leukocyte Surface Marker Detection, Cell Conjugation, Activation and Alloproliferation. Biomaterials 74(1):167-177 (2016).
Le, Y., Toyofuku, W.M. and Scott, M.D. Immunogenicity of Murine mPEG-Red Blood Cells and the Risk of Anti-PEG Antibodies in Human Blood Donors. Experimental Hematology 47(3):36-47 (2017).
Scott, M.D., Toyofuku, W.M., Yang, X., Raj, M. and Kang, N. Chapter X: Immunocamouflaged Red Blood Cells: Polymer-Based Bioengineering of Allogeneic Erythrocytes for Use in Alloimmunized Patients. In: Transfusion Medicine (Editor: Koopman-van Gemert, A.), INTECH Book,
ISBN 978-953-51-5473-0 (2017)
Kang, N., Guo, Q., Islamzada, E., Ma, H., and Scott, M.D., Microfluidic determination of lymphocyte vascular deformability: Effects of intracellular complexity and early immune activation. Integrative Biology, 10:207-217 (2018).
Kang, N., Toyofuku, W.M., Yang, X. and Scott, M.D. Inhibition of Allogeneic Cytotoxic T Cell (CD8+) Proliferation Via Polymer-Induced Treg (CD4+) Cells. Acta Biomaterialia, 57:146–155 (2017).
Yang, X., Kang, N., Toyofuku, W.M., and Scott, M.D. Enhancing the Pro-Inflammatory Anti-Cancer T Cell Response Via Biomanufactured, Secretome-Based, Immunotherapeutics. Immunobiology, (2019). In press